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GLP-1 constipation results from the drug's effect on gut motility, by slowing gastric emptying and intestinal transit, stool moves more slowly through the colon, allowing more water absorption and producing harder, less frequent bowel movements

You can also perform physical therapy at home by following exercises that strengthen muscles around the sore joint

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Weight loss is rarely just physical

Maintaining muscle protein synthesis during a caloric deficit is always beneficial, and resistance training has well-established cardiovascular benefits that I write about regularly

It is hypothesized that the decreased -receptor density leads to subsensitivity of the -adrenergic pathway and therefore decreased muscle contraction 34