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Meta-analyses suggest that GLP-1RAs can lead to an average BMI reduction of 12 kg/m 2 , a decrease in waist circumference of several centimeters, and total weight loss of 5%7% in some studies (85)

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While united by a common mechanism, these agents vary significantly in their molecular structure, size, and half-lifeproperties that may influence their ability to penetrate the blood-retinal barrier (BRB) (Table 1)

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