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doi: 10.7748/ns.2025.e12464

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According to FDA prescribing information and pivotal clinical trials (SURPASS and SURMOUNT programs), injection site reactions are among the documented adverse effects of tirzepatide

Studies document reduced appetite, decreased hunger ratings, and enhanced satiety through combined hypothalamic effects of GIP and GLP-1 receptor activation

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New GLP-1 medications entering the market could change the calculus entirely