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Hypertension and dyslipidaemia were more frequently reported in the GLP1-RA exposed and in the reference group with diabetes

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Eli Lilly must first compile a comprehensive New Drug Application containing all Phase 1, 2, and 3 trial data, manufacturing specifications, proposed labeling, and safety analyses

Another concern was significantly increased cholesterol levels within 12 weeks after OCA treatment, which required concomitant statin therapy and returned to baseline after stopping medication

84 Although current findings are inconsistent, the potential severity of non-arteritic anterior ischemic optic neuropathy warrants the need for trials specifically designed to assess this outcome using standardized and well-defined diagnostic criteria
