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The mitochondria exhibited cristae loss, membrane rupture, and mitochondrial swelling, which was observed with an increase in ATP abundance, complex I activity, and deficiency in the activities of complexes II and IV

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GLP-1 receptor agonists can trigger heartburn and reflux in some patients by slowing stomach emptying and increasing intragastric pressure

Here, the authors report on the allosteric targeting of receptors to avoid this and demonstrate application in drug delivery across the blood brain barrier.