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Higher doses cause more inhibition in this dose-dependent effect

The down-regulation response to adenosine is not mediated through G-protein-coupled adenosine receptors, but occurs through an increase in tyrosine protein phosphatase activity resulting in a decrease in the tyrosine phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen activated protein kinase (MAPK) that leads to an alteration in DPP4 mRNA

This finding also underscores the probability that its most potent effects are mediated peripherally ( in vivo in humans

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Effects of liraglutide on appetite, food preoccupation, and food liking: results of a randomized controlled trial

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