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If you are concerned about testosterone stability while on GLP-1 therapy, work with your endocrinologist or primary care physician to monitor levels every 48 weeks during initial semaglutide therapy and adjust your testosterone dose if needed

Combination or titration arms help establish whether balanced multi-agonism yields supra-additivity or simply layers independent effects

Madrigal Pharmaceuticals Enters into Exclusive Global License Agreement for Oral GLP-1 Receptor Agonist with CSPC Pharmaceutical Group Limited. July 30, 2025.

The real benefit of GLP-1 therapy lies in the opportunity it provides

The good news is that these indirect risks are entirely manageable
