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Elevated insulin stimulates excessive androgen production in the ovaries, suppressing follicle development and triggering excess facial hair, acne, and hair loss

These medications produce 15-21% average body weight reduction in clinical trials numbers that were unthinkable from pharmacotherapy even five years ago

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A 2025 study from the University of British Columbia found that semaglutide users had a 52% higher risk of hair loss compared to users of other weight loss medications, with women experiencing more than twice the risk of men

For some individuals, accepting slightly lower efficacy in exchange for significantly better tolerability makes sense

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