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The authors used non-obese diabetic (NOD) mice that are actually more a model for type 1 diabetes mellitus [11]
Step 3: Preparation of H-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)- Val-Ser(tBu)-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(Boc)- Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-Resin (3-31) Fmoc-Arg(Pbf)-OH (18 gm) was dissolved in DMF (125 ml) at 25-30C
Substitution of Lys with Arg at position 34 prevents C18 fatty acid binding at the wrong site
**Stimulates hepatic fat oxidation** -- your liver breaks down stored fat more aggressively 3
[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Egecioglu E., Steensland P., Fredriksson I., Feltmann K., Engel J., Jerlhag E
