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Sometimes, rare side effects that were not seen in trials can show up after the drug is on the market

Long-term randomized clinical trials of incretin-mimetic drugs with cancer incidence or progression endpoints would be logistically challenging but clinical intervention studies with tissue and circulating biomarker endpoints are justified

Females predominated (n = 18,907, 65.3%) over males (n = 8,838, 30.5%)

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