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These findings informed the phase II and III study recommendations to administer oral semaglutide in the fasting state with up to 120 mL water and wait for 30 min post-dose before eating or ingesting other oral medications [39, 57, 59,60,61,62]

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Recent prescribing patterns underscore this trend

[15] [16] The MHRA has issued important warnings about the risk of neuropsychiatric reactions (including sleep disturbances, depression, agitation, and suicidal thoughts)

Conclusions In SUSTAIN and PIONEER combined, glucagonlike peptide1 analogue semaglutide showed consistent effects on MACE versus comparators across varying CV risk