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The European Medicines Agency added a NAION warning to the Ozempic label that same month after reviewing safety data involving semaglutide and reported optic nerve injuries

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Abbreviations T2D type 2 diabetes GLP-1 glucagon-like peptide 1 RA receptor agonist GIP gastric inhibitory polypeptide GCG glucagon RCT randomized controlled trial PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analysis PROSPERO International Prospective Register of Systematic Reviews BMI body mass index HbA1c glycated hemoglobin SBP systolic blood pressure DBP diastolic blood pressure HDL high-density lipoprotein LDL low-density lipoprotein VLDL very-low-density lipoprotein AST aspartate aminotransferase ALT alanine aminotransferase TEAEs treatment-emergent adverse events Rob-2 Cochrane Collaboration tool for assessing risk of bias in randomized trials GRADE Grading of Recommendation, Assessment, Development and Evaluation WMD weighted mean difference SMD standardized mean difference RR risk ratio CI confidence interval 1

[PubMed] [Google Scholar] 52

The epidemiology of rhegmatogenous retinal detachment: geographical variation and clinical associations