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In pancreatic -cells [58] and ischaemic coronary vascular cells [59], activating GLP-1R promoted mitochondrial respiration, while in astrocytes, GLP-1R activation suppressed mitochondrial oxidative phosphorylation stimulated by -amyloid peptides [60]
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Semaglutide (the active ingredient in Wegovy and Ozempic) and especially Tirzepatide (the active ingredient in Zepbound and Mounjaro), which acts on both GLP-1 and another hormone called GIP, have shown higher average weight loss percentages
All treatment decisions are made by licensed providers based on clinical evaluation and individual health needs
But the marginal benefit over 8mg is small, and the marginal cost in side effects is real
