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Even brief exposure to high heat causes rapid degradation that cannot be reversed by returning the vial to the fridge

Safety Profile, Side Effects, and Guidance The most common side effects are gastrointestinal, including nausea, vomiting, and diarrhoea

[DOI] [PubMed] [Google Scholar] 261.Phillips, A

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As a result, mechanical stress accelerates cartilage breakdown and promotes inflammation
