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For many patients, the 1.7 mg dose delivers meaningful appetite suppression and weight management effects, making dose reduction a viable compromise

Some practitioners use a strategy of reaching target weight with full-dose GLP-1, then gradually reducing to a GLP-1 maintenance dose while continuing HRT

Changes in Food Preferences and Ingestive Behaviors after Glucagon-like Peptide-1 Analog Treatment: Techniques and Opportunities. International Journal of Obesity

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GLP-1 can concurrently stimulate local inhibitory GABA neurons, which indirectly suppress neurons via agouti-related peptide/neuropeptide Y (AgRP + /NPY + ) signalling, thereby reducing feelings of hunger

Among the mechanisms, our research group and others have demonstrated that the gut microbiota fermentation (i.e., bacterial digestion of specific compounds) of specific prebiotics or other non-digestible carbohydrates is associated with the secretion of enteroendocrine peptides, such as the glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by L-cells