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Eli Lillys triple agonist demonstrated an average weight loss of 16.8% in a Phase 3 trial for the treatment of type 2 diabetes.

That meant looking for small molecules that unlike peptides can be more readily absorbed into the bloodstream

Oral semaglutide was shown to be cost effective, with an incremental cost-effectiveness ratio (ICER) of SEK239,001 per quality-adjusted life-year (QALY) compared with empagliflozin and SEK120,848 per QALY compared with sitagliptin, from a payer perspective