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The team of Ralf Jockers in collaboration with the team of Dr Amlie Bonnefond from the European Genomic Institute for Diabetes (EGID, Lille, France), the Huazhong University of Science and Technology (Wuhan, China), the Baylor College of Medicine (Houston, USA) and Imperial College Lonodon (UK) performed a large-scale functional genetics analysis of 60 rare GLP1R mutations

Reducing hyperinsulinemia attenuates its stimulatory effect on ovarian steroidogenesis, thereby alleviating the hyperandrogenic load at its source

December 2020

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Key terms include: $150 million upfront payment to Yao Pharma Up to $1.935 billion in development, regulatory, and commercial milestone payments Tiered royalties on future global sales Coverage across all therapeutic, diagnostic, and prophylactic indications for both human and veterinary use This structure positions the agreement as one of the larger oral-GLP-1 licensing deals in recent years