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As weight loss with any existing pharmaceutical intervention inevitably plateaus due to putative counterregulatory mechanisms, we further hypothesized that the postulated enhanced body weight suppressive effects of combined amylin- and GLP-1R-based pharmacotherapies could be even further enhanced if the drugs were introduced in a stepwise fashion, allowing the physiological systems to adjust to and overcome the tachyphylaxis that occurs with repeated drug treatments 21,22,23

However, there have been increasing reports of clinical cases of regurgitation and/or aspiration of gastric contents during induction of general anesthesia and extubation

Clinical trials show 15-22% average body weight loss with tirzepatide regardless of brand

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