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Its activation contributes to retatrutides enhanced weight loss compared to GLP-1-only medications, but also influences alcohol absorption patterns through effects on gut motility

[PubMed] [Google Scholar] 25.Emerging pharmacotherapies for obesity: a systematic review [Online ahead of print] Kokkorakis M, Chakhtoura M, Rhayem C, Al Rifai J, Ghezzawi M, Valenzuela-Vallejo L, Mantzoros CS

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Tirzepatide activates GLP-1 and GIP receptors simultaneously, engaging dual-pathway activation that can overcome single-pathway desensitization
