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Our results indicated a no observed adverse effect level (NOAEL) of 2 nmol/kg/day for Ex-4 and a maximal tolerated dose (MTD) of 20 nmol/kg/day

Macronutrient composition is the primary driver of GLP-1 release

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Grunwald J, Riva C, Martin D, Quint A, Epstein P

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GIP activation appears to complement GLP-1 effects synergistically rather than additively, which explains why Tirzepatide (dual agonist) produces significantly more weight loss than Semaglutide (single agonist) despite both activating GLP-1