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Although Glp1r expression is mostly localized to endothelial cells in the mouse aorta (29), other vascular cell types may express Glp1r under atherogenic conditions, making it difficult to pinpoint which cell type mediates the antiinflammatory effects of GLP-1 medicines

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323,324,325 Specifically, activation of GLP-1R leads to an increase in cAMP levels, which in turn activates PKA, a widely regulating enzyme of cellular functions, capable of phosphorylating a variety of target proteins, thereby initiating the PKA/CREB signaling pathway

Gastrointestinal intolerance, particularly nausea and vomiting, may affect adherence despite their tendency to diminish over time (Liu et al., 2022)

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