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Description
Since the FDA approved Wegovy in 2021 and Zepbound in 2023, public awareness of GLP-1 drugs have surged

They also lead to significant loss of muscle mass

Diabetes-related cognitive impairment is divided into three stages: diabetes-associated cognitive decrements, mild cognitive impairment (MCI), and dementia

In line with this, the gastric emptying delay induced by GLP-1RAs is dependent on the presence of GLP-1Rs on these vagal afferents (Imeryuz et al., 1997)

It is important to note that the side effect profile can vary considerably depending on the specific bacterial strains, colony-forming unit (CFU) count, and additional ingredients in the formulation

In a clinical trial, one-year dulaglutide treatment in individuals with chronic kidney disease (CKD) and T2D resulted in an increased estimated glomerular filtration rate compared to insulin glargine