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10.1038/s41386-019-0531-4 [DOI] [PMC free article] [PubMed] [Google Scholar] Zorrilla, E

Glucagonlike peptide1 receptor agonists in adult patients with type 2 diabetes: review of cardiovascular outcome trials

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Additionally, it has been shown to enhance symptoms, improve physical fitness, and lower inflammation and body weight in patients with obesity and heart failure with preserved ejection fraction (Kosiborod et al., 2023)

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48 In the Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) trial in adult participants with obesity but without T2DM, tirzepatide (10 mg or 15 mg) achieved greater weight loss compared with semaglutide (1.7 mg or 2.4 mg weekly dose): 20.2% (95% CI 21.4 to 19.1) versus -13.7% (95% CI 14.9 to 12.6) at week 72