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Thome J., Reducing CV Events With Antihyperglycemic Drugs in Patients With Diabetes Mellitus, US Pharmacist 43, no

Improper storage is the most common reason for degradation
P T 38 , 525534 (2013)
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Since brain GLP-1R signaling is to a large extent directly triggered by its peripheral secretion from the intestines via vagal stimulation of the NTS neurons, it seems plausible that proper balance in gut microbiota abundance and diversity can influence action of this peptide in the central nervous system