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An exploratory study with sitagliptin and the GLP-1 receptor agonist liraglutide did not show additive effects, and whether there may be additional effects using shorter acting GLP-1 receptor agonists and DPP-4 inhibitors has not been studied yet (7072, 86)

1 GLP-1Rs are found on a variety of cells including those of the endocrine pancreas, keratinocytes, endothelial cells, neurons, astrocytes, microglia, pancreatic beta-cells, intraepithelial lymphocytes, neutrophils, and eosinophils

GLP-1 analogs on beta-cells: Glucose dependent insulin secretion For nearly 2 decades now, GLP-1 has been heavily investigated as the most promising therapy target in type 2 diabetes patients

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Retrieved July 18, 2026 from www.sciencedaily.com

Data Availability: All relevant data are within the paper and its Supporting Information files