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doi: 10.3389/fimmu.2023.1148209

Several mechanisms may be involved in this potential association, some of which include sudden weight loss and hyperactivity of the hypothalamic-pituitary-adrenal axis
p = 0.022), especially in patients at high CV risk (age 65 years, T2D duration 10 years and BMI 30 kg/m 2 ), but not the other DPP-4is, suggesting a differential effect of each DPP-4 inhibitor on the risk of HF [151]
doi: 10.1002/jnr.21483 34 HamiltonAPattersonSPorterDGaultVAHolscherC

3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Zhang et al., 2023)

Yes, Saxenda is approved for weight loss