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175 Mitochondrial dysfunction is a defect in the early stage of PD and mainly includes impairment of the mitochondrial electron transport chain, alterations in mitochondrial morphology and dynamics, mutations in mitochondrial DNA, and anomalies in calcium homeostasis, 176 which are closely related to the PD phenotype

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This condition affects approximately 1220% of diabetic patients and significantly increases the risk of heart failure and cardiovascular mortality [72]

They are made based on a personalized prescription that may not be commercially available elsewhere or when a drug appears on the FDAs shortage list

"Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation"