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Tang, S

Thus, in perfect agreement with the recent ADA-EASD consensus report [6], we also encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with established ASCVD (coronary artery disease, cerebrovascular disease, or peripheral arterial disease) or multiple risk factors for ASCVD (i.e., age 55 years, obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria) whose HbA1c remains suboptimal despite initial treatment with only one of these agents

According to The Journal of Clinical Endocrinology & Metabolism (09/2025), this type of hair loss is self-limiting for most patients

Regarding retatrutide specifically, whilst it is reasonable to ask your clinician about emerging treatments, it is important to understand that no licensed or regulated supply exists in the UK at present

With the highest 12 mg dose of retatrutide (Eli Lilly) an investigational #GLP1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptor agonist nearly two-thirds of participants lost 20% or more of their body weight, half of participants lost 25% of their body weight and one-quarter of participants lost more than 30% of their body weight

Two therapies currently under development and/or regulatory review: Insulin icodec Efsitora alfa Important note: Availability and regulatory approval status may vary by country, and some therapies remain under clinical investigation