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Topline data from the Phase 3, open-label EMBER-3 clinical trial among patients with estrogen receptor 1 (ESR1) gene mutations who received prior endocrine therapy revealed a median progression-free survival (PFS) of 5.5 months with imlunestrant compared to 3.8 months with placebo (hazard ratio [HR], 0.62

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For Contrave, it was the COR-1 trial that showed Contraves benefits for obesity and weight management

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Regarding lipotoxicity, a study in kidneys of mice fed a high-fat diet (55) revealed that the GLP-1 receptor agonist dulaglutide changed the lipid content of the organ, including reductions in diacylglycerols, phosphatidic acids, phosphatidylglycerols, and triglycerides

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