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In SUSTAIN-7, a study comparing semaglutide to dulaglutide in patients with inadequately controlled T2DM, a greater reduction in body weight was observed with 0.5 mg semaglutide (4.6 kg, standard error [SE] 0.28) compared with 0.75 mg dulaglutide (2.3 kg, SE 0.27) (estimated treatment difference [ETD] 2.26 kg, 95% CI 3.02 to 1.51

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However, severe vomiting, persistent abdominal pain, signs of dehydration, or symptoms lasting beyond 3 weeks warrant immediate provider evaluation to rule out pancreatitis, gastroparesis, or other serious conditions