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If the label includes a titration caution or if community physicians default to the 4 mg or 8 mg maintenance dose out of caution, the population-average weight loss Retatrutide actually produces could compress meaningfully below the 28.7% headline

[DOI] [PubMed] [Google Scholar] 61.Rigamonti A.E., Piscitelli F., Aveta T., Agosti F., De Col A., Bini S., Cella S.G., Di Marzo V., Sartorio A

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Forward-Looking Statements: this article reflects information available in July 2026

10.1038/s41366-024-01646-9 17

doi:10.1016/S0140-6736(23)01163-7 Davies MJ, Bajaj HS, Broholm C, et al