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Switching requires new titration (812 weeks), may temporarily restart GI side effects, and will need insurance reauthorization but the mechanism shift from dual to triple agonism may produce meaningful additional weight loss

The most frequently reported issues: Nausea Vomiting Constipation Diarrhea Acid reflux Reduced sensation of thirst, which can worsen constipation if patients arent actively drinking enough water Janey Pratt, MD, a clinical professor of surgery at Stanford Medicine who performs bariatric surgery on adolescents at Lucile Packard Childrens Hospital Stanford, said nearly all her young patients have some degree of side effects

Defective desmosomes disrupt intercellular junctions which lead to myocyte detachment and myocyte death, and this process is especially exaggerated by mechanical stress like exercise

The calculator includes novel variables, such as chronic kidney disease, history of migraines, severe mental illness, erectile dysfunction, and family history of premature ASCVD