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We therefore conducted an updated systematic review and NMA of European Medicines Agency (EMA) approved obesity management medications (OMMs) available in Europe, incorporating evidence published up to 21 November 2025 to reassess their comparative efficacy and safety for body weight reduction and obesity-related complications in adults

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However, this data is crucial for calculating appropriate dosing for many drugs, especially weight-based medications, and for assessing clinical appropriateness

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