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Given the pathogenic association between insulin resistance and MASLD, and overlap with obesity and type 2 diabetes, glucose-lowering agents targeting insulin resistance, adipose tissue dysfunction, and the incretin system have been studied for treatment of MASLD/MASH [11]

Consumers with the following priorities may wish to compare this model with traditional in-person care or other treatment pathways: Preference for FDA-approved products exclusively: Consumers who prefer to use only FDA-approved finished products that have undergone the agency's full premarket approval process can access branded GLP-1 medications such as Wegovy or Zepbound through a primary care physician or in-person specialist, where FDA-approved formulations can be prescribed and filled at traditional retail pharmacies

Besides all the various conditions of reimbursement that often apply in case of coverage, such as proof of the existence of co-morbidities, prior authorization, patient cost-sharing and indication restrictions, frequently employers and others will want the formulary templates to be tailored in such a way as to reflect their specific demands

Other Sweeteners: How Does It Compare

Tirzepatide generally produces more weight loss than semaglutide, and some experts note that this could help explain the slightly higher rate of hair thinning observed