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4 The second A1C tier between 7.6% and 9.0% lists the use of a GLP-1 analogue or metformin as initial treatment or later as a component of triple therapy

Both contain semaglutide, but they are not taken in the same way and should not be switched without clinical advice

[DOI] [PubMed] [Google Scholar] 24.Cavin J-B, Couvelard A, Lebtahi R, Ducroc R, Arapis K, Voitellier E, Cluzeaud F, Gillard L, Hourseau M, Mikail N, Ribeiro-Parenti L, Kapel N, Marmuse J-P, Bado A, Le Gall M

Indirect mechanisms have also been proposed, particularly in the context of androgen deficiency

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