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Some of the more common side effects in clinical trials compared to placebo include: Gastrointestinal side effects such as nausea, vomiting, constipation, or diarrhea Abdominal pain Headache, dizziness Fatigue Dyspepsia, abdominal distension, eructation Hypoglycemia (low blood sugar) in patients with type 2 diabetes Flatulence, gastroenteritis, and gastroesophageal reflux disease (heartburn) Hypoglycemia (low blood sugar levels), a more serious side effect of GLP-1 drugs, may also occur