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There are some important contraindications for taking GLP-1 medications: a severe allergic reaction to a GLP-1 medication in the past a history of pancreatitis pregnancy or breastfeeding a history of medullary thyroid cancer or multiple endocrine neoplasia type 2 in yourself or an immediate family member Finally, cost and access need to be considered

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The peptides for weight loss and muscle gain article explores strategies for preserving lean mass during GLP-1 therapy

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Each has a slightly different receptor profile and pharmacokinetic profile, but all share the core GLP-1 mechanism