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Published online February 25, 2025:r390
If you smoke, cessation is strongly advised, as tobacco use weakens the lower esophageal sphincter and worsens reflux
This pattern reflects receptor adaptation rather than permanent changes
Although the importance of GIP in metabolic regulation has long been recognized, progress in developing GIP as a therapeutic target has been limited
Neuropathic pain, on the other hand, tends to be chronic and less sharp
Those with less responsive variants benefit from earlier escalation to higher doses or combination therapy, avoiding wasted months on subtherapeutic regimens
