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Its a powerful incretin in its own right, but, this discussion will focus on GLP-1

The SURMOUNT-5 trial demonstrated that Zepbounds dual-agonist approach produces approximately 6% more weight loss compared to Wegovys GLP-1-only mechanism

The one notable sentiment in patient accounts is the standard 3-month beyond-use date on vials, which some patients find limiting, but is standard for 503A sterile compounding.

The trial, TRIUMPH-4, reported a mean body-weight reduction of 28.7% at 68 weeks in participants taking the 12 mg weekly dose

However, it is important to note that Phase 2 trials are smaller and designed primarily to establish dosing and safety, not to provide definitive efficacy data

From this model, the direct effect of semaglutide versus placebo on eGFR (hence, independent of change in body weight) was estimated
