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doi: 10.1007/s11892-013-0418-4 19 YoungVEiserCJohnsonBBrierleySEptonTElliottJet al

doi:10.1016/j.tins.2005.06.005 23
For most healthy individuals, a sustained 5 to 10 BPM increase is the cardiovascular equivalent of mild background stress, significant enough to measure, but not significant enough to cause harm in a healthy heart

Kuhre, R

And evidence suggests stopping the drugs seems to reverse many of those health benefits as well

GLP-1 Studies looking at changes in reward responses in association with GLP-1 mainly focused on metabolic disorders
