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While growth hormone can influence fat metabolism and muscle mass, clinical research on Sermorelin has primarily focused on treating growth hormone deficiency and anti-aging, rather than weight loss

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[1] [2] It works by mimicking the naturally occurring hormone GLP-1, which regulates appetite and food intake by acting on receptors in the brain, pancreas, and gastrointestinal tract

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Time window and exit rules: a sufficient treatment window (36 months) should be reserved to achieve clinically meaningful weight loss (typically threshold of 5%10%) alongside IR improvement

Retatrutide: Significant weight loss, increased satiety, and glucose control