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In addition, GLP-1RAs inhibit the NLRP3 inflammasome (which is implicated in multiple NDDs

The multidisciplinary team of GI providers, gut-brain specialists, and registered dietitians at Oshi Health can offer a tailored treatment plan to help you implement the lifestyle and behavioral adjustments needed to reduce GI side effects associated with GLP-1 drugs

The timing of GLP-1 administration may influence the tolerability of these symptoms, though this has not been definitively established in clinical trials

The medications are likely acting directly on these pathways

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However, their effectiveness is greatest when combined with long-term nutrition, physical activity, sleep optimization, and sustainable lifestyle changes