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Data from observational studies and subgroup analyses of RCTs show that GLP-1 RAs reduce HF outcomes and mortality in obese HF patients across the LVEF spectrum

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These pathways are commonly reviewed in laboratory models involving receptor interaction, glucose response, metabolic signalling and energy balance research

In 2023 ADA guidelines said that, alongside lower hypoglycemia and obesity, GLP-1 agonists are highly recommended drugs among patients with clinical ASCVD risks (eg, prior myocardial infarction, stroke), as they lower cardiovascular risk

Although the medications primary mechanism is to regulate blood sugar and suppress appetite, hormonal fluctuations or immune responses induced by the drug may contribute to changes in skin condition