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What the 2025 Gastroenterology Metaanalysis Found The systematic review and metaanalysis (DOI: 10.1053/j.gastro.2025.06.003) evaluated safety outcomes across randomized trials and realworld studies of GLP1 RAs

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Such improvements are crucial in mitigating the risk of obesity-related comorbidities, notably cardiovascular diseases and type 2 diabetes, which stand as leading contributors to global morbidity and mortality

Conclusions Severe obesity adversely influences CRC staging, operative complexity, and perioperative outcomes

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