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Description
Large cardiovascular outcome trials, including LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide), have demonstrated cardiovascular risk reduction with GLP-1 receptor agonists
GLP1 infusion in rats was shown to increase renal blood flow, eGFR, and urine output in a PKA-dependent manner

Why GLP-1 Medications Can Make Symptoms Worse GLP-1 medications can amplify these issues in a few ways: Changes in appetite and eating patterns Increased sensitivity to fullness and pressure Altered breathing patterns due to discomfort Increased abdominal guarding or bracing When breathing mechanics shift and the diaphragm is not moving well, pressure is often redirected outward into the abdomen instead of being managed efficiently within the system

This overview explains what GLP-1s are commonly prescribed for and outlines options employees may consider if insurance coverage is limited or unavailable

This is critical

About 1 in 8 adults are now taking a GLP-1 drug for obesity, disease, or both, up 6 percentage points from May 2024, according to KFF poll results released in November
