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Interesting data arose from sub- and meta-analyses of RCTs regarding renal protection, cardiovascular safety, non-alcoholic fatty liver disease (NAFLD), and cognitive impairment

Diabetes 59:479485 Schfer SA, Mssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

Since the discovery of insulin, the main goal of diabetes treatment has been the control of glycaemia to prevent complications

You exercise to exhaustion, lose some pounds and gain them back

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55 Apart from the weight reduction, GLP-1RAs have been shown to exert antihypertensive effects by promoting diuresis and having additional renal effects