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It remains to be determined whether this compensatory increase in OFC recruitment stems from negative energy balance, and/or whether this outcome impacts long-term weight maintenance

PlexusDx's Precision Peptide Genetic Test reveals predispositions in key peptide-signaling variants (GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, MC4R rs17782313) that may help provide context for treatment planning

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GIP may enhance weight loss by directly targeting its receptor in the central nervous system to regulate appetite, enhancing GLP-1s anorectic action, and reducing drug-induced nausea in order to improve the tolerability of and compliance to GLP-1 receptor agonists [45]

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