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The clinical data is overwhelming

A C18 diacid fatty acid chain (octadecanedioic) is then grafted on lysine 26 via a -Glu-2xOEG spacer (glutamic acid + two 8-amino-3,6-dioxaoctanoic units)

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One of the most prominent issues is the high rate of adverse events such as nausea, diarrhea, constipation, abdominal pain, and other gastrointestinal adverse effects

However, their effects on gastrointestinal motility may lead to adverse events, including gastroparesis and pancreatitis [3]