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Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice

Weight loss induced by GLP-1 medications represents an indirect but clinically relevant interaction

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The drug has a long half-life, which means it can be administered monthly or less frequently, giving the drug the potential to improve adherence and long-term weight control, according to Jay Bradner, executive vice president of research and development at Amgen

Understanding potential interactions between magnesium supplementation and GLP-1 medications, as well as other commonly prescribed drugs, is essential for safe and effective treatment

The glucagon receptor raises theoretical concerns about heart rate increases (glucagon is known to increase heart rate), but clinical trial data has not shown significant safety issues in this regard so far