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Conclusion GI AEs are the most common effects of GLP-1 RAs and dual GIP/GLP-1 RAs, often manifesting during initiation and dose escalation
Clinical trial data from large cardiovascular outcome studiesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide)have not demonstrated increased fracture risk among patients taking GLP-1 receptor agonists compared with placebo

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The degree of regain depends heavily on what habits were established during the treatment period

When given to obese mice, LY3437943 decreased body weight and enhanced glycemic/blood sugar control
